Journal: International Journal of Women's Health
Article Title: Live Births Following IVF-FET in Two Adult Sisters with Nonclassic P450 Oxidoreductase Deficiency: A Case Report Identifying a Novel POR Variant
doi: 10.2147/IJWH.S580471
Figure Lengend Snippet: Controlled ovarian stimulation (COS) regimens and hormonal profiles of the two sisters. Schematic timelines illustrate the ovarian stimulation protocols in Case 1 (elder sister) and Case 2 (younger sister). Colored horizontal bars represent different medication phases: brown bars indicate dydrogesterone administration; blue bars indicate triptorelin acetate; green bars indicate recombinant FSH stimulation. Yellow arrows indicate the timing of ovulation trigger (rHCG injection). The white boxes on the right summarize serum hormone levels and endometrial thickness on the trigger day. The x-axis represents the days of menstruation. Both patients exhibited premature progesterone elevation at trigger, necessitating a freeze-all strategy.
Article Snippet: A short GnRH agonist protocol was applied, using triptorelin acetate (Diphereline, Ipsen Pharma, France) in combination with recombinant FSH (Gonal-F, Merck Serono, Switzerland) 150 IU/day from cycle day 3 for 9 days, with a total gonadotropin dose of 1350 IU.
Techniques: Recombinant, Injection